Blar i forfatter "Eken, Torsten"

Viser treff 1-5 av 5

    • Biphasic release of the alarmin high mobility group box 1 protein early after trauma predicts poor clinical outcome 

      Ottestad, William Arne; Rognes, Ingrid Nygren; Pischke, Søren; Mollnes, Tom Eirik; Andersson, Ulf; Eken, Torsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08)
      <i>Objective</i>: The causal role of the prototype alarmin high mobility group box 1 protein (HMGB1) in systemic inflammation and remote organ injury after trauma and shock is established in animal models but not in humans. Our aim was therefore to determine HMGB1 concentration kinetics with high time resolution during the first hours after trauma in individual patients, and investigate the ...

    • Forskjeller i mortalitet hos traumepasienter 

      Wisborg, Torben; Dehli, Trond; Eken, Torsten; Brattebø, Guttorm; Johnsen, Lars Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-16)
      Mortaliteten blant norske traumepasienter i perioden 2015–18 var på linje med de beste resultatene fra andre land, men fortsatt fant vi regionale forskjeller og forskjeller mellom sykehusnivåer. Selv om resultatene er bra, kan vi bli bedre. Traumer er den viktigste dødsårsaken for personer under 44 år på verdensbasis, også i vår del av verden. Mortalitet er et internasjonalt anerkjent effektmål ...

    • Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study 

      Rognes, Ingrid Nygren; Pischke, Søren Erik; Ottestad, William; Røislien, Jo; Berg, Jens Petter; Johnson, Christina; Eken, Torsten; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-08)
      Background - Complement activation is a central mechanism in systemic inflammation and remote organ dysfunction following major trauma. Data on temporal changes of complement activation early after injury is largely missing. We aimed to describe in detail the kinetics of complement activation in individual trauma patients from admission to 10 days after injury, and the association with trauma ...

    • Mortality after hospital admission for trauma in Norway: A retrospective observational national cohort study 

      Dehli, Trond; Wisborg, Torben; Johnsen, Lars Gunnar; Brattebø, Guttorm; Eken, Torsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-28)
      Background - National quality data for trauma care in Norway have not previously been reported. We have therefore assessed crude and risk-adjusted 30-day mortality in trauma cases after primary hospital admission on national and regional levels for 36 acute care hospitals and four regional trauma centres.<p> <p>Methods - All patients in the Norwegian Trauma Registry in 2015–2018 were included. ...

    • Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study 

      Sundnes, Olav; Ottestad, William Arne; Schjalm, Camilla; Lundbäck, Peter; La Cour Poulsen, Lars; Mollnes, Tom Eirik; Haraldsen, Guttorm; Eken, Torsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-26)
      Background - Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, including multiple trauma. In this study we explored high-resolution concentration kinetics of the alarmin interleukin-33 (IL-33) early after human trauma.<p> <p>Methods - ...